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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	colorectal cancer
ICD-0-3	C19.9
Methods	qPCR, Dual luciferase assay, Western blot, Cell proliferation assay, Cell apoptosis assay
Sample	colorectal cancer tissues, cell lines (Caco-2, COLO205, COLO320HSR, DLD-1, HCT-15, HT-29, SW480, SW620, LoVo), normal intestinal cell lines (FHC, NCM460), HCT-8, LS 174T, and SW1116
Expression Pattern	down-regulated
Function Description	the expression of circRNA hsa_circ_0000523 (also known as circ_006229) was down-regulated in different colorectal cancer cell lines. It was also found that interference of hsa_ circ_0000523 induced proliferation and suppressed apoptosis of colorectal cancer cells, the proliferation rate of which was reduced by the overexpression of hsa_circ_0000523. In addition, we found that miR-31 could recognize hsa_circ_0000523 sequence and that it acted as a sponge of miR-31, indirectly regulating Wnt/b-catenin signaling pathway, which was involved in the progression of colorectal cancer. The results suggested that the expression of hsa_circ_0000523 correlated to the tumorigenesis of colorectal cancer cells. In addition, as a sponge of miR-31, the low level of hsa_circ_0000523 led to activation of Wnt/b-catenin signaling pathway, inducing the subsequent progress of colorectal cancer.
Pubmed ID	30403259
Year	2018
Title	Circular RNA hsa_circ_0000523 regulates the proliferation and apoptosis of colorectal cancer cells as miRNA sponge

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