Basic Information
| LncRNA/CircRNA Name | circDTL |
| Synonyms | circ_0000179 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | medulloblastoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, CCK-9, Cell migration and invasion assays |
| Sample | MB tissues, MB DAOY cell lines |
| Expression Pattern | differentially expressed |
| Function Description | This study provided evidence that two critical differentially expressed circRNAs, circ-SKA3 and circ-DTL, were crucial in promoting cell proliferation, migration, and invasion in MB, possibly through a novel mechanism of regulating the expression of host genes, thereby shedding light on target therapy and potential personal intervention for MB.Upregulated circ-SKA3 and circ-DTL promoted the proliferation migration and invasion in vitro by regulating the expression of host genes. |
| Pubmed ID | 30402980 |
| Year | 2018 |
| Title | Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes |
External Links
| Links for circDTL | GenBank HGNC NONCODE |
| Links for medulloblastoma | OMIM COSMIC |