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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	pancreatic ductal adenocarcinoma
ICD-0-3	C25.3
Methods	RT-qPCR, CCK??, Cell apoptosis and caspase??/?? activity assays, Transwell assays, Western blot assays, luciferase reporter assay
Sample	PDAC tumor tissues, PDAC cell lines (BxPC3, Capan??, AsPC??, PANC1, and SW1990), Pancreatic duct epithelial cell (HPDE)
Expression Pattern	up-regulated
Function Description	circ_0007534 was overexpressed not only in PDAC tissues but also in a panel of PDAC cell lines, and this overexpression is closely associated with advanced tumor stage and positive lymph node invasion. In addition, circ_0007534 may be regarded as an independent prognostic factor for patients with PDAC. For the part of functional assays, circ_0007534 significantly increased cell proliferation, migratory, and invasive potential of PDAC cells. Circ_0007534 could inhibit cell apoptosis partly via a Bcl 2/caspase 3 pathway. The xenograft study further confirmed the cell growth promoting the role of circ_0007534. Mechanistically, miR 625 and miR 892b were sponged by circ_0007534. The oncogenic functions of circ_0007534 is partly dependent on its regulation of miR 625 and miR 892b.
Pubmed ID	30382592
Year	2018
Title	Upregulated circular RNA circ_0007534 indicates an unfavorable prognosis in pancreatic ductal adenocarcinoma and regulates cell proliferation, apoptosis, and invasion by sponging miR??25 and miR??92b

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