Basic Information
| LncRNA/CircRNA Name | circ_0136666 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT??CR, CCK??, Colony formation assay, Flow cytometric analysis, Wound healing assay, In vitro invasion assay, Luciferase reporter assay, RNA pull??own assay, Western blot |
| Sample | CRC tissues, CRC cell lines (LoVo, SW480, HCT116, SW620, HT29, HCT8, and DLD1) and normal colon epithelial cell line FHC |
| Expression Pattern | up-regulated |
| Function Description | through circRNA high throughput sequencing and quantitative real time polymerase chain reaction, we identified that hsa_circ_0136666 was significantly overexpressed in CRC tissues and cell lines. High hsa_circ_0136666 expression was associated with poor overall survival of patients with CRC. In vitro function assays showed that hsa_circ_0136666 inhibition suppressed CRC cell proliferation, migration, invasion, and arrested CRC cells in the G0/G1 phase. Furthermore, we showed that hsa_circ_0136666 inhibition reduced CRC cell growth in vivo. Mechanistically, we revealed that hsa_circ_0136666 could increase SH2B1 expression via competitively binding miR 136 in CRC cells. In addition, SH2B1 overexpression could reverse the effects of hsa_circ_0136666 inhibition on CRC cell progression. |
| Pubmed ID | 30370521 |
| Year | 2018 |
| Title | Hsa_circ_0136666 promotes the proliferation and invasion of colorectal cancer through miR??36/SH2B1 axis |
External Links
| Links for circ_0136666 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |