Basic Information
| LncRNA/CircRNA Name | circ_0058063 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qRT??CR, MTT assay, Flow cytometry, Wound??ealing assay, Dual luciferase reporter assay, Western blot, Xenografts in mice |
| Sample | BC tissues, BC cell lines T24 and J82 |
| Expression Pattern | up-regulated |
| Function Description | Circ_0058063 was significantly overexpressed in BC tissues.?The downregulation of circ_0058063 impaired BC cell proliferation and migration ability but improved cell apoptosis ability.?Circ_0058063 repressed miR 145 5p, which inhibited the expression of CDK6.?Downregulation of circ_0058063 or miR-145-5p transfection contributed to more cells arresting in G0/G1 stage.?MiR 145 5p suppressed cell growth and migration ability in BC, whereas CDK6 exerted the opposite influence on these cellular events.?In vivo experiment also indicated that tumor development in BALB/c nude mice was repressed remarkably when circ_0058063 was downregulated. |
| Pubmed ID | 30362519 |
| Year | 2018 |
| Title | Circ_0058063 regulates CDK6 to promote bladder cancer progression by sponging miR??45??p |
External Links
| Links for circ_0058063 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |