Detail

Basic Information

LncRNA/CircRNA Name	circ_0008309
Synonyms
Region
Ensemble
Refseq

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	Oral squamous cell carcinoma
ICD-0-3	C06.9
Methods	RT-qPCR, Western blotting
Sample	frozen OSCC tissues, SCC15 and CAL27 cell lines
Expression Pattern	down-regulated
Function Description	Hsa_circ_0008309 was significantly downregulated in 45 pairs of OSCC tissue samples and was statistically correlated with pathological differentiation. The bioinformatics databases suggested that hsa_circ_0008309 could combine with miR-1290, miR-136-5P, and miR-382-5P, respectively, to regulate the expression of ATXN1. It was subsequently identified that hsa_circ_0008309 may inhibit miR-136-5P and miR-382-5P expression and increase ATXN1 expression in the OSCC cell lines
Pubmed ID	30344795
Year	2018
Title	Hsa_circ_0008309 May Be a Potential Biomarker for Oral Squamous Cell Carcinoma

External Links

Links for circ_0008309	GenBank HGNC NONCODE
Links for Oral squamous cell carcinoma	OMIM COSMIC