Detail
| LncRNA Name | AFAP1-AS1 |
| Synonyms | AFAP1-AS1, AFAP1-AS, AFAP1AS, LOC84740, MGC10981 |
| Region | GRCh38_4:7754090-7778928 Sequence |
| Ensembl | ENSG00000272620 |
| RefSeq | NR_026892 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | esophageal adenocarcinoma |
| ICD-0-3 | C15 M8140/3 |
| Methods | qPCR etc. |
| Sample | EAC tissues, cell lines (OE-33, SK-GT-4, FLO-1, HEEpiC etc.) |
| Expression Pattern | up-regulated |
| Function Description | Using quantitative reverse-transcription PCR, we assessed expression levels of AFAP1-AS1 in 20 matched pairs of human EAC and adjacent NE as well as in 12 matched pairs of human benign BE and adjacent NE. AFAP1-AS1 expression was elevated relative to NE in the majority of EACs (15/20) and BEs (11/12). These data suggest that AFAP1-AS1 expression is up-regulated in both EAC cell lines and primary EAC tissues, consistent with the DNA hypomethylation observed in these same samples. BE and EAC exhibit reduced methylation that includes non-coding regions. Methylation of the long noncoding RNA AFAP1-AS1 is reduced in BE and EAC, and its expression inhibits cancer-related biologic functions of EAC cells. |
| Pubmed ID | 23333711 |
| Year | 2013 |
| Title | Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma. |
| External Links |
| Links for AFAP1-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for esophageal adenocarcinoma | Omim Cosmic |
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