Detail
| LncRNA Name | ENST00000547963 |
| Synonyms | LINC01234, LCAL84, onco-lncRNA-32 |
| Region | GRCh38_12:113679459-113773683 Sequence |
| Ensembl | ENSG00000249550 |
| RefSeq | NR_110026 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | gastric cancer tissues, cell lines (GES-1, BGC823, SGC7901, AGS, HGC27, MGC803) |
| Expression Pattern | up-regulated |
| Function Description | LINC01234 expression was significantly upregulated in gastric cancer tissues and was associated with larger tumor size, advanced TNM stage,lymph node metastasis,and shorter survival time.Furthermore,knockdown of LINC01234-induced apoptosis and growth arrest in vitro and inhibited tumorigenesis in mouse xenografts.Mechanistic investigations indicated that LINC01234 functioned as a ceRNA for miR-204-5p,thereby leading to the derepression of its endogenous target core-binding factor B (CBFB). LINC01234 is significantly overexpressed in gastric cancer, and LINC01234-miR-204-5p-CBFB axis plays a critical role in gastric cancer tumorigenesis. |
| Pubmed ID | 29386218 |
| Year | 2018 |
| Title | Long Noncoding RNA LINC01234 Functions as a Competing Endogenous RNA to Regulate CBFB Expression by Sponging miR-204-5p in Gastric Cancer. |
| External Links |
| Links for ENST00000547963 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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