Detail
| LncRNA Name | EWSAT1 |
| Synonyms | EWSAT1, LINC00277, NCRNA00277, TMEM84, FLJ33768 |
| Region | GRCh38_15:69072926-69095820 Sequence |
| Ensembl | ENSG00000212766 |
| RefSeq | NR_026949 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | Ewing sarcoma |
| ICD-0-3 | M9260/3 |
| Methods | microarray, qPCR, Western blot, RIP etc. |
| Sample | cell lines (pMPCs, PSS090 and TC71) |
| Expression Pattern | up-regulated |
| Function Description | Expression of EWS-FLI1 and EWSAT1 repressed gene expression, and a substantial fraction of targets that were repressed by EWS-FLI1 were also repressed by EWSAT1. Analysis of RNAseq data from primary human Ewing sarcoma further supported a role for EWSAT1 in mediating gene repression. We identified heterogeneous nuclear ribonucleoprotein (HNRNPK) as an RNA-binding protein that interacts with EWSAT1 and found a marked overlap in HNRNPK-repressed genes and those repressed by EWS-FLI1 and EWSAT1, suggesting that HNRNPK participates in EWSAT1-mediated gene repression. |
| Pubmed ID | 25401475 |
| Year | 2014 |
| Title | Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis |
| External Links |
| Links for EWSAT1 | GenBank HGNC lncrnadb Noncode |
| Links for Ewing sarcoma | Omim Cosmic |
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