Detail
| LncRNA Name | AFAP1-AS1 |
| Synonyms | AFAP1-AS1, AFAP1-AS, AFAP1AS, LOC84740, MGC10981 |
| Region | GRCh38_4:7754090-7778928 Sequence |
| Ensembl | ENSG00000272620 |
| RefSeq | NR_026892 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc. |
| Sample | GC tissues, cell lines (AGS, MGC-803, SGC-7901, and BGC-823) |
| Expression Pattern | up-regulated |
| Function Description | A small interfering RNA (siRNA) that targeted AFAP1-AS1 was transfected into cells to inhibit the expression of AFAP1-AS1. AFAP1-AS1 was up-regulated in GC tissues and GC cells. AFAP1-AS1 knockdown suppressed cell viability of SGC7901 transfected with si-AFAP1-AS1. AFAP1-AS1 was up-regulated in GC cells and regulated the gastric cancer cell proliferation and apoptosis via PTEN/p-AKT pathway. AFAP1-AS1 was found to be associated with increased risk of developing lymph node metastasis, poor overall survival, and short recurrence-free survival. |
| Pubmed ID | 28451917 |
| Year | 2017 |
| Title | Long Noncoding RNA AFAP1-AS1 Promotes Cell Proliferation and Apoptosis of Gastric Cancer Cells via PTEN/p-AKT Pathway. |
| External Links |
| Links for AFAP1-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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