Detail
| LncRNA Name | EWSAT1 |
| Synonyms | EWSAT1, LINC00277, NCRNA00277, TMEM84, FLJ33768 |
| Region | GRCh38_15:69072926-69095820 Sequence |
| Ensembl | ENSG00000212766 |
| RefSeq | NR_026949 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Cell transfection, Western blot, Luciferase reporter assay, RNA pull-down assay etc. |
| Sample | NPC tissues, cell lines (SUNE-1, CNE-1, HNE-1, CNE-2, C666-1 and HONE-1) |
| Expression Pattern | up-regulated |
| Function Description | Herein, we identified that EWSAT1 was up-regulated in NPC tissues and cell lines, and higher expression of EWSAT1 resulted in a markedly poorer survival time. EWSAT1 over-expression facilitated, while EWSAT1 silencing impaired cell growth in NPC. In addition, mechanistic analysis demonstrated that EWSAT1 up-regulated the expression of miR-326/330-5p clusters targeted gene cyclin D1 through acting as a competitive 'sponge' of miR-326/330-5p clusters. |
| Pubmed ID | 27816050 |
| Year | 2016 |
| Title | Long non-coding RNA EWSAT1 promotes human nasopharyngeal carcinoma cell growth in vitro by targeting miR-326/-330-5p. |
| External Links |
| Links for EWSAT1 | GenBank HGNC lncrnadb Noncode |
| Links for nasopharyngeal cancer | Omim Cosmic |
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