Detail
| LncRNA Name | FABP5P3 |
| Synonyms | NA |
| Region | GRCh38_7:152436895-152443187 Sequence |
| Ensembl | ENSG00000241735 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell line (LO2, Hep3B, HepG2, Huh7), HCC tissues |
| Expression Pattern | up-regulated |
| Function Description | FABP5P3 that was up-regulated in HCC tissues.Patients with higher FABP5P3 expression displayed poorer survival rate.FABP5P3 depletion in HCC cell lines and sample cells remarkably inhibited the abilities of proliferation, migration and invasion. FABP5P3 bond to miR-589-5p which served as a tumor suppressor. MiR-589-5p targeted directly the mRNA of ZMYND19 whose function has not been defined in HCC.FABP5P3 promoted HCC development and progression by sponging miR-589-5p and up-regulating ZMYND19 expression.FABP5P3/miR-589-5p/ZMYND19 axis regulates cell proliferation and migration in HCC,which may serve as a new target for HCC treatment. |
| Pubmed ID | 29522715 |
| Year | 2018 |
| Title | LncRNA FABP5P3/miR-589-5p/ZMYND19 axis contributes to hepatocellular carcinoma cell proliferation, migration and invasion. |
| External Links |
| Links for FABP5P3 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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