Detail
| LncRNA Name | FAL1 |
| Synonyms | FALEC, FAL1, LINC00568, ncRNA-a1 |
| Region | GRCh38_1:150515757-150518032 Sequence |
| Ensembl | ENSG00000228126 |
| RefSeq | NR_051960 |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (LO2, SMMC-7721, Huh7, HepG2, HepG2.2.15), HCC tissues |
| Expression Pattern | up-regulated |
| Function Description | lncRNA FAL1 was up-regulated in HCC tissues and functioned as an oncogene in HCC.LncRNA FAL1 could accelerate cell proliferation and metastasis as a ceRNA mechanism by competitively binding to miR-1236. Moreover,lncRNA FAL1 was also up-regulated in serum exosome of HCC patients and could transfer lncRNA FAL1 to HCC cells to increase their abilities of cell proliferation and migratio. |
| Pubmed ID | 29421439 |
| Year | 2018 |
| Title | LncRNA FAL1 promotes cell proliferation and migration by acting as a CeRNA of miR-1236 in hepatocellular carcinoma cells. |
| External Links |
| Links for FAL1 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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