Detail
| LncRNA Name | FAM83H-AS1 |
| Synonyms | FAM83H-AS1, onco-lncRNA-3 |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NR_033849 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 M8140/3 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay, Cell proliferation assay, Cell migration and invasion assay etc. |
| Sample | LAD tissues, cell lines (HCC4006, H1975, H358, H44, H1650 etc.) |
| Expression Pattern | up-regulated |
| Function Description | FAM83H-AS1 was found to be overexpressed in tumors relative to normal lung and significantly associated with worse patient survival in LUAD. Cell proliferation, migration and invasion were decreased after FAM83H-AS1 knockdown using siRNAs in lung cancer cells. Flow cytometry analysis indicated the cell cycle was arrested at the G2 phase after FAM83H-AS1 knockdown. Mechanistically, we found that MET/EGFR signaling was regulated by FAM83H-AS1. |
| Pubmed ID | 28198463 |
| Year | 2017 |
| Title | Overexpression of FAM83H-AS1 indicates poor patient survival and knockdown impairs cell proliferation and invasion via MET/EGFR signaling in lung cancer. |
| External Links |
| Links for FAM83H-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for lung adenocarcinoma | Omim Cosmic |
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