Detail
| LncRNA Name | FENDRR |
| Synonyms | FENDRR, FOXF1-AS1, TCONS_00024240, lincFOXF1, onco-lncRNA-21 |
| Region | GRCh38_16:86474529-86509099 Sequence |
| Ensembl | ENSG00000268388 |
| RefSeq | NR_033925 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Luciferase reporter assay, in vitro knockdown |
| Sample | cell lines (RWPE-1, P69 ,VCaP, LNCaP, 22Rv1, PC3, DU145), PCa tissues |
| Expression Pattern | down-regulated |
| Function Description | FENDRR acts as a molecular sponge for miR-18a-5p. Upregulation of FENDRR inhibited cell proliferation, increased apoptosis and decreased invasion and migration ability,which was inhibited by miR-18a-5p mimic. Knockdown of FENDRR resulted in a significant increase of PCa cell proliferation and decrease of apoptosis and this effect was inhibited miR-18a-5p inhibitor.FENDRR and RUNX1 contain potential target sites for miR-18a-5p. miR-18a-5p mimic inhibited RUNX1 expression and luciferase activity.FENDRR could increase RUNX1 expression,which was inhibited by miR-18a-5p.The effect of FENDRR on cell proliferation, apoptosis and invasion and migration ability was suppressed by silence of RUNX1. |
| Pubmed ID | 29465000 |
| Year | 2018 |
| Title | Long non-coding RNA FENDRR reduces prostate cancer malignancy by competitively binding miR-18a-5p with RUNX1. |
| External Links |
| Links for FENDRR | GenBank HGNC lncrnadb Noncode |
| Links for prostate cancer | Omim Cosmic |
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