Detail
| LncRNA Name | FER1L4 |
| Synonyms | FER1L4, C20orf124 |
| Region | GRCh38_20:35558737-35607562 Sequence |
| Ensembl | ENSG00000088340 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | gastric cancer tissues, cell lines (AGS, MGC-803, SGC-7901) |
| Expression Pattern | down-regulated |
| Function Description | We observed that FER1L4 was downregulated in gastric cancer and that its level corresponded with that of PTEN mRNA. Both FER1L4 and PTEN mRNA were targets of miR-106a-5p. Further experiments demonstrated that FER1L4 downregulation liberates miR-106a-5p and decreases the abundances of PTEN mRNA and protein. More importantly, FER1L4 downregulation accelerated cell proliferation by promoting the G0/G1 to S phase transition. |
| Pubmed ID | 26306906 |
| Year | 2015 |
| Title | Long noncoding RNA FER1L4 suppresses cancer cell growth by acting as a competing endogenous RNA and regulating PTEN expression. |
| External Links |
| Links for FER1L4 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.