Detail
| LncRNA Name | FER1L4 |
| Synonyms | FER1L4, C20orf124 |
| Region | GRCh38_20:35558737-35607562 Sequence |
| Ensembl | ENSG00000088340 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | microarray, qPCR, RNAi etc. |
| Sample | gastric cancer tissues, cell lines (GES-1, AGS, MGC-803, SGC-7901 etc.) |
| Expression Pattern | differential expression |
| Function Description | RB1 is one of miR-106a-5p's targets, and has been validated by dual luciferase reporter assay25. In this study, the interaction between FER1L4 and miR-106a-5p was first predicted by miRcode. Then dual luciferase reporter assay showed that the luciferase activity of the mutant FER1L4 plasmid was about 56% higher than that of the wild-type plasmid. This indicated that the mutations introduced in the seed matches impair the ability of miR-106a-5p to bind to FER1L4. qRT-PCR analysis revealed that transfection of small interfering RNA (siRNA) against FER1L4 not only reduced FER1L4 levels in GES-1, AGS, MGC-803 and SGC-7901, but also reduced RB1 levels in all cells tested. |
| Pubmed ID | 25124853 |
| Year | 2014 |
| Title | Long noncoding RNA associated-competing endogenous RNAs in gastric cancer. |
| External Links |
| Links for FER1L4 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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