Detail
| LncRNA Name | FEZF1-AS1 |
| Synonyms | NR_036484 |
| Region | GRCh38_7:122303658-122310077 Sequence |
| Ensembl | ENSG00000230316 |
| RefSeq | NR_036484 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✔ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Western blot, RIP, ChIP, MTT assay etc. |
| Sample | gastric cancer tissues, cell lines (MGC-803, SGC-7901, AGS) |
| Expression Pattern | up-regulated |
| Function Description | FEZF1-AS1 was overexpressed in gastric cancer. Further experiments revealed that knockdown FEZF1-AS1 significantly inhibited gastric cancer cells proliferation by inducing G1 arrest and apoptosis, whereas endogenous expression FEZF1-AS1 promoted cell growth. Additionally, RIP assay and RNA-pulldown assay evidenced that FEZF1-AS1 could epigenetically repress the expression of P21 via binding with LSD1, the first discovered demethylase. |
| Pubmed ID | 28209170 |
| Year | 2017 |
| Title | LincRNAFEZF1-AS1 represses p21 expression to promote gastric cancer proliferation through LSD1-Mediated H3K4me2 demethylation. |
| External Links |
| Links for FEZF1-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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