Detail
| LncRNA Name | FEZF1-AS1 |
| Synonyms | NR_036484 |
| Region | GRCh38_7:122303658-122310077 Sequence |
| Ensembl | ENSG00000230316 |
| RefSeq | NR_036484 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | multiple myeloma |
| ICD-0-3 | C42.1 M9732/3 |
| Methods | qPCR, RIP, Western blot, Luciferase reporter assay etc. |
| Sample | multiple myeloma tissues, cell line (OPM-2, U266, KM3, U1996, H929), |
| Expression Pattern | up-regulated |
| Function Description | FEZF1-AS1 expression was increased both in MM samples and cell lines. Loss of functional assays indicated that FEZF1-AS1 suppression inhibited MM cells proliferation, arrested cell cycle in G0/G1 phase and induced cell apoptosis in vitro. Furthermore, our data indicated that FEZF1-AS1 functioned as a competing endogenous RNA in MM cells that regulated miR-610 expression, which suppressed Akt3. Those data showed that FEZF1-AS1 promoted MM cells proliferation through regulating miR-610/Akt3 axis, suggesting FEZF1-AS1 could be served as a potential target for cancer therapeutics in MM. |
| Pubmed ID | 29864963 |
| Year | 2018 |
| Title | Long non-coding RNA FEZF1-AS1 promotes cell growth in multiple myeloma via miR-610/Akt3 axis. |
| External Links |
| Links for FEZF1-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for multiple myeloma | Omim Cosmic |
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