Detail
| LncRNA Name | FGFR3-AS1 |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | RT-qPCR, Western blot, in vitro knockdown |
| Sample | human liver cancer cell lines (SMMC-7721, BEL-7404 (7404), Huh7, Hep3B and HepG2 ) |
| Expression Pattern | up-regulated |
| Function Description | FGFR3-AS1 knockdown significantly inhibited cell proliferation but induced apoptosis.Moreover,FGFR3-AS1 knockdown led to more HCC cells arrested in G0 stage. Besides, FGFR3-AS1 knockdown significantly inhibited cell migration and invasion. Additionally,we found that FGFR3-AS1 silence dramatically delayed tumor growth in vivo.In mechanism, we found FGFR3-AS1 silence decreased the activation of PI3K/AKT signaling pathway.LncRNAs could regulate cell proliferation,apoptosis, migration and invasion by sponging miRNAs or interacting with specific proteins.Furthermore, western blot (WB) results indicated that FGFR3-AS1 knockdown promoted the expression of P21 but inhibited CYCLIN D1 expression. |
| Pubmed ID | 29463348 |
| Year | 2018 |
| Title | Long non-coding RNA FGFR3-AS1 promotes hepatocellular carcinoma carcinogenesis via modulating PI3K/AKT pathway. |
| External Links |
| Links for FGFR3-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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