Detail
| LncRNA Name | FOXC2-AS1 |
| Synonyms | FOXC2-AS1, ODRUL |
| Region | GRCh38_16:86565145-86567761 Sequence |
| Ensembl | ENSG00000260944 |
| RefSeq | NR_125795 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot etc. |
| Sample | cell line (MCF-10A, MDA-MB-468, MDA-MB-231, MDA-MB-436, MCF-7), BC tissue |
| Expression Pattern | up-regulated |
| Function Description | Cyclin D1 Cyclin D2, and Cyclin D3 were all partly positively modulated by FOXC2-AS1 in BC. FOXC2-AS1 may serve as a promising prognostic biomarker and therapeutic target for BC patients. FOXC2-AS1 significantly suppressed the proliferation ability and flow cytometric analysis illustrated the influence of FOXC2-AS1 on cell cycle and apoptosis rate. |
| Pubmed ID | 29562954 |
| Year | 2018 |
| Title | Long non-coding RNA FOXC2-AS1 predicts poor survival in breast cancer patients and promotes cell proliferation |
| External Links |
| Links for FOXC2-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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