Detail
| LncRNA Name | FOXC2-AS1 |
| Synonyms | FOXC2-AS1, ODRUL |
| Region | GRCh38_16:86565145-86567761 Sequence |
| Ensembl | ENSG00000260944 |
| RefSeq | NR_125795 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR, microarray, Western blot, Luciferase reporter assay etc. |
| Sample | cell lines (SaoS2, HOS, U2-OS, MG63, 143B) |
| Expression Pattern | up-regulated |
| Function Description | ODRUL is upregulated in OS tissues and cell lines and correlates with poor prognosis. A microarray screen combined with online database analysis showed that miR-3182 is upregulated and MMP2 is downregulated in sh-ODRUL-expressing MG63 cells and that miR-3182 harbors potential binding sites for ODRUL and the 30 UTR of MMP2 mRNA. In addition, miR-3182 expression and function are inversely correlated with ODRUL expression in vitro and in vivo. A luciferase reporter assay demonstrated that ODRUL could directly interact with miR-3182 and upregulate MMP2 expression via its competing endogenous RNA activity on miR-3182 at the posttranscriptional level. |
| Pubmed ID | 28750740 |
| Year | 2017 |
| Title | LncRNA ODRUL Contributes to Osteosarcoma Progression through the miR-3182/MMP2 Axis |
| External Links |
| Links for FOXC2-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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