Detail
| LncRNA Name | FOXD3-AS1 |
| Synonyms | FOXD3-AS1, pasFOXD3 |
| Region | GRCh38_1:63320884-63324441 Sequence |
| Ensembl | ENSG00000230798 |
| RefSeq | NR_121634 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | neuroblastoma |
| ICD-0-3 | M9500/3 |
| Methods | RNA-Seq, qPCR, Western blot, Luciferase reporter assay,in vitro knockdown, RIP etc. |
| Sample | cell lines (NB-1643, SK-N-BE(2), NB-1691, IMR32,BE(2)-C, SK-N-AS, SH-SY5Y, SK-N-SH), NB tissue |
| Expression Pattern | down-regulated |
| Function Description | FOXD3-AS1 is downregulated in NB tissues and cell lines, and ectopic expression of FOXD3-AS1 induces neuronal differentiation and decreases the aggressiveness of NB cells in vitro and in vivo.Mechanistically, as a nuclear lncRNA, FOXD3-AS1 interacts with poly(ADP-ribose) polymerase 1 (PARP1) to inhibit the poly(ADP-ribosyl)ation and activation of CCCTC-binding factor (CTCF), resulting in derepressed expression of downstream tumor-suppressive genes. FOXD3-AS1 harbors tumor-suppressive properties by inhibiting the oncogenic roles of PARP1 or CTCF and plays crucial roles in all-trans-retinoic-acid-mediated therapeutic effects on NB. |
| Pubmed ID | 29398485 |
| Year | 2018 |
| Title | Risk-Associated Long Noncoding RNA FOXD3-AS1 Inhibits Neuroblastoma Progression by Repressing PARP1-Mediated Activation of CTCF |
| External Links |
| Links for FOXD3-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for neuroblastoma | Omim Cosmic |
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