Detail
| LncRNA Name | FOXD3-AS1 |
| Synonyms | FOXD3-AS1, pasFOXD3 |
| Region | GRCh38_1:63320884-63324441 Sequence |
| Ensembl | ENSG00000230798 |
| RefSeq | NR_121634 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | glioma tissues, cell lines (U87, A172 and U251) |
| Expression Pattern | up-regulated |
| Function Description | FOXD3-AS1 was markedly up-regulated in high-grade glioma tissues (WHO grade III-IV) compared with that in low-grade glioma (WHO grade I-II) and normal brain tissues, and patients with low FOXD3-AS1 expression had grater survival probability. FOXD3-AS1 knockdown significantly inhibited cell proliferation, induced cell cycle S-phase arrest, and impaired cell migration and invasion in malignant glioma cells. As expected, we also found that the expression of FOXD3-AS1 was positively correlated with FOXD3 mRNA. Knockdown of FOXD3-AS1 reduced the protein level of FOXD3 in cultured U251 and A172 cell lines. |
| Pubmed ID | 27829996 |
| Year | 2016 |
| Title | Down-regulation of long non-coding RNA FOXD3 antisense RNA 1 (FOXD3-AS1) inhibits cell proliferation, migration, and invasion in malignant glioma cells. |
| External Links |
| Links for FOXD3-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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