Detail
| LncRNA Name | AFAP1-AS1 |
| Synonyms | AFAP1-AS1, AFAP1-AS, AFAP1AS, LOC84740, MGC10981 |
| Region | GRCh38_4:7754090-7778928 Sequence |
| Ensembl | ENSG00000272620 |
| RefSeq | NR_026892 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR,etc. |
| Sample | The normal human mammary epithelial cell line (MCF-10A). 4 breast cancer cell lines (MCF-7,SK-RB-3,MDA-MB231,MDA-MB-468). A total of 160 paired breast cancer tissue,adjacent normal tissue. |
| Expression Pattern | up-regulated |
| Function Description | Up-regulated lncRNA AFAP1-AS1 indicates a poor prognosis in breast cancer patients and regulated the breast cancer cells proliferation, apoptosis and metastasis. AFAP1-AS1 knockdown can inhibit the proliferation,metastasis and promote apoptosis of MCF-7. However,the AFAP1 expression and actin filament integrity was not affected after AFAP1-AS1 knockdown.The Kaplanā??Meier method was used to estimate survival curves,the log-rank test wasused to compare between groups. |
| Pubmed ID | 29974352 |
| Year | 2018 |
| Title | Up-regulated lncRNA AFAP1-AS1 indicates a poor prognosis and promotes carcinogenesis of breast cancer. |
| External Links |
| Links for AFAP1-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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