Detail
| LncRNA Name | FTH1P3 |
| Synonyms | FTH1P3, FTHL3, FTHL3P |
| Region | GRCh38_2:27392784-27393367 Sequence |
| Ensembl | ENSG00000213453 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR,Flow cytometry assay,Western blot,Luciferase reporter assay,etc. |
| Sample | Human breast cancer cell lines (MCF-7,MDA-MB-231,MDA-MB-468,MDA-MB-453) and normal human breast epithelial cell (MCF-10A) were purchased from ATCC (Manassas,VA,USA). breast cancer tumorous tissue. |
| Expression Pattern | up-regulated |
| Function Description | Bioinformatics tools and luciferase reporter assay validated that,FTH1P3 promoted ABCB1 protein expression through targeting miR-206,acting as,a miRNA sponge. In summary,our results reveal the potential regulatory mechanism ,of FTH1P3 on breast cancer paclitaxel resistance through miR-206/ABCB1,providing a novel insight for the breast cancer chemoresistance. However,the occurrence of chemoresistance causes the poor prognosis,high recurrence rate and low 5-year survival rate.In the present study,we investigate the role of lncRNA FTH1P3 in breast cancer paclitaxel resistance and explore the underlying mechanism for the drug resistance generation. |
| Pubmed ID | 29971911 |
| Year | 2018 |
| Title | Long non-coding RNA FTH1P3 activates paclitaxel resistance in breast cancer through miR-206/ABCB1. |
| External Links |
| Links for FTH1P3 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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