Detail
| LncRNA Name | FTX |
| Synonyms | FTX, LINC00182, MIR374AHG, NCRNA00182, FLJ33139 |
| Region | GRCh38_X:73946555-74293574 Sequence |
| Ensembl | ENSG00000230590 |
| RefSeq | NR_028379 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi etc. |
| Sample | CRC tissues, cell lines (HT-29, SW1116, SW480, COLO205) |
| Expression Pattern | up-regulated |
| Function Description | Long non-coding RNA FTX was significantly upregulated in colorectal cancer tissues, and low long non-coding RNA FTX expression was significantly correlated with differentiation grade, lymph vascular invasion, and clinical stage. Patients with high long non-coding RNA FTX showed poorer overall survival than those with low long non-coding RNA FTX. Multivariate analyses indicated that status of long non-coding RNA FTX was an independent prognostic factor for patients. Functional analyses showed that upregulation of long non-coding RNA FTX significantly promoted growth, migration, invasion, and increased colony formation in colorectal cancer cells. |
| Pubmed ID | 26629053 |
| Year | 2015 |
| Title | Biological significance of long non-coding RNA FTX expression in human colorectal cancer |
| External Links |
| Links for FTX | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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