Detail
| LncRNA Name | FTX |
| Synonyms | FTX, LINC00182, MIR374AHG, NCRNA00182, FLJ33139 |
| Region | GRCh38_X:73946555-74293574 Sequence |
| Ensembl | ENSG00000230590 |
| RefSeq | NR_028379 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | M9861/3 |
| Methods | Microarray, qPCR, Western blot, Flow cytometry assay, RIP, etc. |
| Sample | AML cell lines(U937, THP-1). |
| Expression Pattern | up-regulated |
| Function Description | The observation suggested that high-mannose N-glycans and mannosyltransferase ALG3 affected drug-resistance in AML cells. FTX/miR-342/ALG3 axis could potentially be used for the targets to overcome therapeutic resistance in AML. Functionally, we found that FTX directly interacted with miR-342 to regulate ALG3 expression and function, including ADR-resistant cell growth and apoptosis. Kaplan�??Meier overall survival curves (OS) was observed based on ALG3 level. Data were the means±SD of triplicate determinants (*p < 0.05). |
| Pubmed ID | 29880818 |
| Year | 2018 |
| Title | Aberrant mannosylation profile and FTX/miR-342/ALG3-axis contribute to development of drug resistance in acute myeloid leukemia. |
| External Links |
| Links for FTX | GenBank HGNC lncrnadb Noncode |
| Links for acute myeloid leukemia | Omim Cosmic |
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