Detail
| LncRNA Name | AB073614 |
| Synonyms | NA |
| Region | GRCh38_3:149173591-149175492 Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | microarray, qPCR, RNAi, Western blot, Flow cytometry assay etc. |
| Sample | ovarain cancer tissues, cell lines (A2780, Caov3, HO-8910, OVCAR3, SKOV3 etc.) |
| Expression Pattern | up-regulated |
| Function Description | Results showed that AB073614 expression was significantly up-regulated in 85.3% (64/75) cancerous tissues compared with normal counterparts. Knockdown of AB073614 expression significantly inhibited cell proliferation and invasion, resulted in cell arrest in G1 phase of cell cycle and a dramatic increase of apoptosis. Finally, western blot assays indicated that lncRNA AB073614 may exert its function by targeting ERK1/2 and AKT-mediated signaling pathway. In conclusion, our study suggests that lncRNA AB073614 acts as a functional oncogene in OC development. |
| Pubmed ID | 26299803 |
| Year | 2015 |
| Title | A long noncoding RNA AB073614 promotes tumorigenesis and predicts poor prognosis in ovarian cancer. |
| External Links |
| Links for AB073614 | GenBank HGNC lncrnadb Noncode |
| Links for ovarian cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.