Detail
| LncRNA Name | GAPLINC |
| Synonyms | GAPLINC, LINC01540, TCONS_00026238, lncRNA-uc002kmd.1 |
| Region | GRCh38_18:3466250-3478978 Sequence |
| Ensembl | ENSG00000266835 |
| RefSeq | NR_110429 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell line (HCT116), CRC tissue |
| Expression Pattern | up-regulated |
| Function Description | GAPLINC expression was obviously increased in CRC tissues.In HCT116, silencing of GAPLINC weakened cell migration and invasion, while overexpression of GAPLINC significantly promoted cell migration and invasion. Through dual-luciferase, RNA pull-down, and Transwell assays, we verified that miR-34a was the downstream molecule of GAPLINC and that miR-34a negatively regulated the migration and invasion of HCT116 cell.Furthermore, we found that GAPLINC positively regulated the miR-34a target gene c-MET in CRC tissues. |
| Pubmed ID | 29427222 |
| Year | 2017 |
| Title | Long Noncoding RNA GAPLINC Promotes Cells Migration and Invasion in Colorectal Cancer Cell by Regulating miR-34a/c-MET Signal Pathway. |
| External Links |
| Links for GAPLINC | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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