Detail
| LncRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 Sequence |
| Ensembl | ENSG00000234741 |
| RefSeq | NR_002578 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, RNAi |
| Sample | cell lines (ATCC, CCL-2,ATCC, CCL-229) |
| Expression Pattern | up-regulated |
| Function Description | Glucocorticoids (GCs) are widely employed in inflammatory, autoimmune and neoplastic diseases; GAS5 was up-regulated in GC-resistant cells and accumulated more in the cytoplasm compared to the nucleus in response to the drug. GAS5 knockdown reduced the proliferation during GC treatment.GAS5 could be considered a novel pharmacogenomic marker useful for the personalization of GC therapy. |
| Pubmed ID | 28722800 |
| Year | 2017 |
| Title | Role of the Long Non-Coding RNA GAS5 in Glucocorticoid Response in Children with Inflammatory Bowel Disease |
| External Links |
| Links for GAS5 | GenBank HGNC lncrnadb Noncode |
| Links for colon cancer | Omim Cosmic |
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