Detail
| LncRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 Sequence |
| Ensembl | ENSG00000234741 |
| RefSeq | NR_002578 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR, Western blot |
| Sample | cell lines (MG-63 and OS-732, hFOB1.19) |
| Expression Pattern | down-regulated |
| Function Description | LncRNA GAS5 was down-regulated in MG-63 and OS-732 cells compared to hFOB1.19 cells.Silence of lncRNA GAS5 significantly promoted MG-63 cells viability,migration and invasion,and up-regulated Cyclin D1,Cyclin B1,CDK1 and CDK4 expressions.miR-203a was negatively regulated by lncRNA GAS5.The promoting activities of lncRNA GAS5 silence on MG-63 cells growth and metastasis were reversed by miR-203a suppression.lncRNA GAS5 silence,miR-203a overexpression,and TIMP2 silence could activate PI3K/AKT/GSK3B signaling while block NF-kB signaling.LncRNA GAS5 might be a tumor suppressor in osteosarcoma via sponging miR-203a,sequestering miR-203a away from TIMP2. |
| Pubmed ID | 29414815 |
| Year | 2018 |
| Title | LncRNA GAS5 Represses Osteosarcoma Cells Growth and Metastasis via Sponging MiR-203a. |
| External Links |
| Links for GAS5 | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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