In current study, we investigated the possible association between susceptibility of lung cancer and GAS5 rs145204276, which showed contradictory roles in carcinogenesis of colorectal cancer and hepatocellular carcinoma. Taken together, our findings provided strong evidence for the hypothesis that GAS5 rs145204276 were significantly associated with the susceptibility of lung cancer, and GAS5 functions as a tumor suppressor in carcinogenesis of lung cancer. In summary, we demonstrated that SNP rs145204276 of GAS5 was associated with decreased risk of lung cancer in the Chinese populations. These findings should be verified by larger, well-designed epidemiologic and functional studies.