Detail
| LncRNA Name | AGAP2-AS1 |
| Synonyms | AGAP2-AS1, PUNISHER, LOC100130776, PUNISHER |
| Region | GRCh38_12:57726271-57728356 Sequence |
| Ensembl | ENSG00000255737 |
| RefSeq | NR_027032 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Western blot, RIP, ChIP, Luciferase reporter assay, Cell proliferation assay, Cell migration and invasion assay etc. |
| Sample | gastric cancer tissues, cell lines (BGC823, SGC7901, AGS, MGC803, and MKN45) |
| Expression Pattern | up-regulated |
| Function Description | AGAP2-AS1 was highly expressed in the GC tissues and cell lines. Knockdown of AGAP2-AS1 significantly inhibited GC cell proliferation, migration, and invasion in vitro and tumor growth in vivo. AGAP2-AS1 overexpression promoted cell growth and invasion. In addition, the transcription factor SP1 activated AGAP2-AS1 expression in the GC cells. AGAP2-AS1 functions as an oncogenic lncRNA by interacting with LSD1 and EZH2 and suppressing CDKN1A (P21) and E-cadherin transcription. |
| Pubmed ID | 28209205 |
| Year | 2017 |
| Title | Long noncoding AGAP2-AS1 is activated by SP1 and promotes cell proliferation and invasion in gastric cancer. |
| External Links |
| Links for AGAP2-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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