Detail
| LncRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 Sequence |
| Ensembl | ENSG00000234741 |
| RefSeq | NR_002578 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 M8140/3 |
| Methods | qPCR, Western blot etc. |
| Sample | lung cancer tissues, cell lines (A549, H1299, H1975, HCC827) |
| Expression Pattern | down-regulated |
| Function Description | Our results showed that GAS5 was significantly downregulated in lung adenocarcinoma tissues compared with the paired adjacent non-tumorous tissue samples. Furthermore, lower GAS5 expression levels were associated with larger tumor sizes, poor tumor differentiation, and advanced pathological stages. GAS5 overexpression was inversely correlated with the expression of the EGFR pathway and IGF-1R proteins. |
| Pubmed ID | 25925741 |
| Year | 2015 |
| Title | The long non-coding RNA, GAS5, enhances gefitinib-induced cell death in innate EGFR tyrosine kinase inhibitor-resistant lung adenocarcinoma cells with wide-type EGFR via downregulation of the IGF-1R expression. |
| External Links |
| Links for GAS5 | GenBank HGNC lncrnadb Noncode |
| Links for lung adenocarcinoma | Omim Cosmic |
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