Detail
| LncRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 Sequence |
| Ensembl | ENSG00000234741 |
| RefSeq | NR_002578 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi etc. |
| Sample | cell lines (AGS1, MGC803, SGC7901 and MKN54), gastric adenocarcinomas tissues |
| Expression Pattern | up-regulated |
| Function Description | Overexpression of tumor suppressor lncRNAs PTENP1-AS and GAS5 might,in turn,reduce the oncogenic role of miR-21.We observed upregulation of PTENP1-AS that could increase the EGFR and AGO4 expression in tumors and also noticed that GAS5 could compete with AGO4 and regulate the miR-21.Compared to PTENP1-AS,the GAS5 expression was predominantly upregulated in the gastric tumor samples and the expression level was comparatively higher than competing mRNA AGO4. Collectively,these observations suggest that overexpression of PTENP1-AS and GAS5 in gastric cancer could be abrogating oncogenic activity of miR-21 and confirms that lncRNAs could act as tumor suppressive ceRNAs. |
| Pubmed ID | 29719612 |
| Year | 2018 |
| Title | Comprehensive analysis of aberrantly expressed lncRNAs and construction of ceRNA network in gastric cancer. |
| External Links |
| Links for GAS5 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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