Detail
| LncRNA Name | GAS5 |
| Synonyms | GAS5, NCRNA00030, SNHG2, ENST00000456293.5, GAS5-007 |
| Region | GRCh38_1:173863900-173868882 Sequence |
| Ensembl | ENSG00000234741 |
| RefSeq | NR_002578 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | breast cancer tissues, cell lines (MDA-MB-453, MDA-MB-231, MCF-7 and T47D) |
| Expression Pattern | down-regulated |
| Function Description | Ten different lncRNAs were applied in this study, which was reported to be associated with Notch-1. The level of these ten lncRNAs in breast tumors and adjacent normal tissues were evaluated, which suggested that HOTAIR and MALAT1 increased most significantly, and LUNAR1 and GAS5 decreased most significantly. High level of Notch-1 provided a poor prognosis in breast cancer. Interference of Notch-1 significantly suppressed proliferation of T47D cell, and significantly increased the level of GAS5. |
| Pubmed ID | 26550436 |
| Year | 2015 |
| Title | Notch-1 promotes breast cancer cells proliferation by regulating LncRNA GAS5. |
| External Links |
| Links for GAS5 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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