Detail
| LncRNA Name | GCRL1 |
| Synonyms | SMIM25ï¼?LINC01272, GCRL1 |
| Region | GRCh38_20: 50267486-50279795 Sequence |
| Ensembl | ENSG00000224397 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, western blot, Luciferase reporter assay etc. |
| Sample | gastric cancer tissues, cell line SGC-7901 |
| Expression Pattern | differential expression |
| Function Description | In this study, we identified the abundantly expressed lncRNA, RP11-290F20.3, in GC cells and patient tumor tissues. We named this lncRNA as GC-related lncRNA1 (GCRL1), which could regulate gastric cell proliferation and metastasis, both in vitro and in vivo. Further, GCRL1 promoted the cell proliferation and metastasis by sponging miR-885-3p and hence, positively regulating CDK4 in GC cells. |
| Pubmed ID | 29789536 |
| Year | 2018 |
| Title | Long noncoding RNA gastric cancer-related lncRNA1 mediates gastric malignancy through miRNA-885-3p and cyclin-dependent kinase 4 |
| External Links |
| Links for GCRL1 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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