A significantly decreased risk of bladder cancer was found for the rs2839698 TC genotype, but not for CC homozygotes. The rs2839698 TC genotype was especially associated with a reduced risk of developing non-muscle-invasive disease. Borderline significantly decreased risks of bladder cancer were found for the rs2107425 CT genotype, but not for TT homozygotes or for T allele carriers of rs217727. Haplotype analysis did not result in stronger associations with bladder cancer compared with the single-locus analyses. An SNP polymorphism in the nonî??protein-encoding H19 gene is associated with a decreased risk of developing nonî??muscleinvasive bladder cancer. This association was found for only heterozygotes, not for homozygotes.