Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | adrenocortical carcinoma |
| ICD-0-3 | M8370/3 |
| Methods | MSP-PCR, Cell proliferation assay etc. |
| Sample | pathological adrenal glands, cell line (NCI-H295R) |
| Expression Pattern | down-regulated |
| Function Description | In the adrenocortical carcinoma cell line NCI-H295R, abundant IGF-II, but minimal H19, RNA expression was detected by Northern blotting. Treatment with a cytosine methylation inhibitor, 5-aza-2'-deoxycytidine, increased H19 RNA expression, whereas it decreased IGF-II mRNA accumulation dose- and time-dependently and reduced cell proliferation to 10% in 7 d. Our results suggest that altered DNA methylation of the H19 promoter is involved in the abnormal expression of both H19 and IGF-II genes in human adrenocortical carcinomas. |
| Pubmed ID | 11889182 |
| Year | 2002 |
| Title | Association of H19 promoter methylation with the expression of H19 and IGF-II genes in adrenocortical tumors. |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for adrenocortical carcinoma | Omim Cosmic |
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