Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | hepatoblastoma |
| ICD-0-3 | C22.0 M8970/3 |
| Methods | qPCR, Northern blot, Southern blot etc. |
| Sample | hepatoblastoma tissues |
| Expression Pattern | down-regulated |
| Function Description | We show here that the expression of the H19 gene is inactivated by maternal allelic loss or hypermethylation in 7 out of 8 sporadic hepatoblastomas. Furthermore, we analyzed expression of the IGF2 gene. Loss of imprinting of the IGF2 gene was detected and linked to inactivation of the H19 gene in 2 hepatoblastomas. However, 2 sporadic cases demonstrated monoallelic expression of the IGF2 gene with inactivation of the H19 gene. Our results suggest that H19 may play a role as a common imprinted tumor suppressor gene in sporadic hepatoblastomas but may at times work independently of IGF2 expression. |
| Pubmed ID | 10404060 |
| Year | 1999 |
| Title | High frequency of inactivation of the imprinted H19 gene in sporadic hepatoblastoma. |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for hepatoblastoma | Omim Cosmic |
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