Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | neuroblastoma |
| ICD-0-3 | M9500/3 |
| Methods | qRT-PCR, Western blot |
| Sample | Human neuroblastoma cell line (SH-SY5Y), 293T cells |
| Expression Pattern | up-regulated |
| Function Description | Expressions of lncRNA-H19 and miR-675 were upregulated in neuroblastoma cells,and were downregulated by AP.AP was also identified to upregulate CD44.We next found AP affected SH-SY5Y cells through downregulating miR-675.Key kinases in the PI3K/AKT and JAK/STAT pathways were downregulated by AP stimulation,while these downregulations were abrogated by miR-675 overexpression. KIF1B isoform B (KIF1BB) is proved to be a target of miR-675. |
| Pubmed ID | 29465760 |
| Year | 2018 |
| Title | Angelica sinensis polysaccharide inhibits proliferation, migration, and invasion by downregulating microRNA-675 in human neuroblastoma cell line SH-SY5Y. |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for neuroblastoma | Omim Cosmic |
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