Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | laryngeal squamous cell cancer |
| ICD-0-3 | C32.3 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | LSCC tissues, cell line (Hep-2) |
| Expression Pattern | up-regulated |
| Function Description | We identified microRNA miR-148a-3p as an inhibitory target for H19. Overexpression of miR-148a-3p reduced LSCC migration, invasion and proliferation cell, while inhibition of miR-148a-3p did the opposite. The inhibition of LSCC progression induced by H19 knockdown required the activity of miR-148a-3p. We also identified DNA methyltransferase enzyme DNMT1 as a target of miR-148a-3p. Cellular DNA methylation levels were inhibited by both miR-148a-3p overexpression and H19 knockdown |
| Pubmed ID | 26872375 |
| Year | 2016 |
| Title | Regulation of laryngeal squamous cell cancer progression by the lncRNA H19/miR-148a-3p/DNMT1 axis |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for laryngeal squamous cell cancer | Omim Cosmic |
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