Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | pancreatic ductal adenocarcinoma |
| ICD-0-3 | C25.3 M8500/3 |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | pancreatic ductal adenocarcinoma tissues |
| Expression Pattern | up-regulated |
| Function Description | the suppressed cell proliferation caused by H19 knockdown could be rescued by inhibiting miR-675 expression.As a transcript of the first exon of H19,the level of miR-675 was negatively correlated with H19 expression in microdissected PDAC tissues.And the decrease of E2F-1 protein expression caused by siH19 could be partially reversed by miR-675 knockdown.there might be a H19/miR-675/E2F-1 regulatory loop in cell cycle modulation. |
| Pubmed ID | 29344285 |
| Year | 2018 |
| Title | Long noncoding RNA H19 derived miR-675 regulates cell proliferation by down-regulating E2F-1 in human pancreatic ductal adenocarcinoma. |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for pancreatic ductal adenocarcinoma | Omim Cosmic |
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