Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR, Western blot, MTT assay etc. |
| Sample | cell line (hFOB1.19) |
| Expression Pattern | down-regulated |
| Function Description | Both H19 and miR-675 levels in hFOB1.19 cells were significantly decreased by overexpression of miR-141 than that in control group, but their expression were reversed by miR-141 inhibitor. In addition, expression of H19 and miR-675 in adjacent tissues were both significantly higher than that in tumor tissues. However, cell viability was significantly decreased by co-transfection of siRNA-H19/miR-675 inhibitor and miR-141 inhibitor compared with the miR-141 inhibitor group with time increasing, suggesting that the promote role of miR-141 inhibitor on cell proliferation may be suppressed by silencing H19 or miR-675 inhibitor. |
| Pubmed ID | 27186302 |
| Year | 2016 |
| Title | miR-141 modulates osteoblastic cell proliferation by regulating the target gene of lncRNA H19 and lncRNA H19-derived miR-675. |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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