Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR, Luciferase reporter assay etc. |
| Sample | thyroid cancer tissues, cell lines (TPC-1, NIM, Nthy-ori 3-1 and BCPAP) |
| Expression Pattern | up-regulated |
| Function Description | Our results suggest that H19 functions as a competitive endogenous RNA (ceRNA) by acting as a sink for miR-17-5p, revealing a potential ceRNA regulatory network involving H19 and miR-17-5p with a role in the modulation of YES1 expression. This mechanism may contribute to a better understanding of thyroid cancer pathogenesis and provide new insights into the treatment of this disease. |
| Pubmed ID | 27093644 |
| Year | 2016 |
| Title | Long noncoding RNA H19 competitively binds miR-17-5p to regulate YES1 expression in thyroid cancer |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for thyroid cancer | Omim Cosmic |
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