Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR etc. |
| Sample | cell lines (MCF10A, RPMI 1640, DMEM H21 etc.) |
| Expression Pattern | up-regulated |
| Function Description | The role of H19 in transformation is addressed using a knockdown approach and shows that down-regulation of H19 significantly decreases breast and lung cancer cell clonogenicity and anchorage-independent growth. In addition, c-Myc and H19 expression shows strong association in primary breast and lung carcinomas. This work indicates that c-Myc induction of the H19 gene product holds an important role in transformation. |
| Pubmed ID | 16707459 |
| Year | 2006 |
| Title | The c-Myc oncogene directly induces the H20 noncoding RNA by allele-specific binding to potentiate tumorigenesis. |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for lung cancer | Omim Cosmic |
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