Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | head and neck squamous cell carcinoma |
| ICD-0-3 | C76.0 M8070/3 |
| Methods | qPCR, Cell transfection, Cell proliferation assay, Cell migration and invasion assay etc. |
| Sample | acute lymphoblastic leukemia tissues |
| Expression Pattern | up-regulated |
| Function Description | We observed that both H19 and miR-675 were significantly overexpressed in a cohort of 65 primary tumor samples and two HNSCC cell lines. Importantly, when paired with patient follow-up data, higher expression of either H19 or miR-675 was significantly correlated with higher risk of patient relapse, and associated with worse overall survival and poor disease-free survival. Knockdown miR-675 caused significant reduction of cell viability, migratory and invasive capabilities. |
| Pubmed ID | 27994496 |
| Year | 2016 |
| Title | Overexpression of lncRNA H19/miR-675 promotes tumorigenesis in head and neck squamous cell carcinoma. |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for head and neck squamous cell carcinoma | Omim Cosmic |
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