Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Cell transfection, Western blot etc. |
| Sample | cell lines (HT-29 and HT-29 resistant cell) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA H19 was found to be significantly upregulated in this resistant cell line. Further investigation showed that H19 knockdown sensitized the MTX resistance in HT-29-R cells while its overexpression improved the MTX resistance in the parental cells, suggesting that H19 mediate MTX resistance. The Wnt/B-catenin signaling was activated in HT-29-R cells, and H19 knockdown suppressed this signaling in the parental cells. |
| Pubmed ID | 27919747 |
| Year | 2017 |
| Title | H19 mediates methotrexate resistance in colorectal cancer through activating Wnt/B-catenin pathway. |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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