Detail
| LncRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 Sequence |
| Ensembl | ENSG00000130600 |
| RefSeq | NR_002196 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✔ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | microarray, qPCR, RIP, ChIP etc. |
| Sample | cell lines (DLD1, HCT116, HT29 and SW480) |
| Expression Pattern | differential expression |
| Function Description | H19 silencing blocked G1-S transition, reduced cell proliferation, and inhibited cell migration. Our experimental data showed that H19 affects phosphorylation of RB1 protein by regulating gene expression of CDK4 and CCND1. We further demonstrated that reduced CDK8 expression underlies changes of B-catenin activity, and identified that H19 interacts with macroH2A, an essential regulator of CDK8 gene transcription. |
| Pubmed ID | 27789274 |
| Year | 2016 |
| Title | H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-B-Catenin Signaling in Colorectal Cancer. |
| External Links |
| Links for H19 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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